Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cardiovascular responses to adenosine in the Antarctic fish Pagothenia borchgrevinki
Responsible organisation
1999 (English)In: Journal of Experimental Biology, ISSN 0022-0949, E-ISSN 1477-9145, Vol. 202, no 17, 2259-2267 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

We have investigated the effects of adenosine on the cardiovascular system of the Antarctic fish Pagothenia borchgrevinki. Continuous measurements of ventral and dorsal aortic blood pressures, heart rate (f(H)) and ventral aortic blood flow (cardiac output, (Q)over dot) were made using standard cannulation techniques and a single-crystal Doppler flowmeter, On line measurements of arterial P-O2 were made using an oxygen electrode connected to an extracorporeal loop. Adenosine (10 nmol kg(-1)) and the specific A(1)-receptor agonist N-6-cyclopentyadenosine (CPA) elicited biphasic changes in the branchial and systemic resistances. While there was an initial decrease in the branchial resistance followed by an increase, the opposite was true for the systemic response. The resistance changes were significantly attenuated by aminophylline (a P-1-receptor antagonist) and 8-cyclopentyltheophylline (CPT; an A(1)-receptor antagonist). In addition, adenosine induced an aminophylline-sensitive decrease in the arterial P-O2. The reduction was attenuated when pre-injection arterial P-O2 was low. Adenosine and CPA also caused a marked reduction in f(H), with CPA being more potent. The bradycardia was blocked by aminophylline and CPT, demonstrating an involvement of A(1) receptors in this response.

Place, publisher, year, edition, pages
1999. Vol. 202, no 17, 2259-2267 p.
Keyword [en]
teleost; Pagothenia borchgrevinki; purinergic; circulation; gill; heart; blood pressure; receptor
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:polar:diva-2901OAI: oai:DiVA.org:polar-2901DiVA: diva2:954464
Available from: 2016-08-22 Created: 2016-08-22 Last updated: 2016-08-22

Open Access in DiVA

No full text

In the same journal
Journal of Experimental Biology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

Total: 14 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf