Late Quaternary paleoceanographic changes at the Lomonosov Ridge, central Arctic Ocean, were reconstructed from a multicore and gravity core recovered during the 2014 SWERUS-C3 Expedition. Ostracode assemblages dated by accelerator mass spectrometry (AMS) indicate changing sea-ice conditions and warm Atlantic Water (AW) inflow to the Arctic Ocean from  ∼  50 ka to present. Key taxa used as environmental indicators include Acetabulastoma arcticum (perennial sea ice), Polycope spp. (variable sea-ice margins, high surface productivity), Krithe hunti (Arctic Ocean deep water), and Rabilimis mirabilis (water mass change/AW inflow). Results indicate periodic seasonally sea-ice-free conditions during Marine Isotope Stage (MIS) 3 ( ∼  57–29 ka), rapid deglacial changes in water mass conditions (15–11 ka), seasonally sea-ice-free conditions during the early Holocene ( ∼  10–7 ka) and perennial sea ice during the late Holocene. Comparisons with faunal records from other cores from the Mendeleev and Lomonosov ridges suggest generally similar patterns, although sea-ice cover during the Last Glacial Maximum may have been less extensive at the new Lomonosov Ridge core site ( ∼  85.15° N, 152° E) than farther north and towards Greenland. The new data provide evidence for abrupt, large-scale shifts in ostracode species depth and geographical distributions during rapid climatic transitions.